Freeware

UWT is the only tweak program I currently use for Vista. If you are going to use this program, PLEASE know what you are tweaking beforehand. As always, backup first.
UWT 1.1 change log, Download & Info.

Process Explorer v11.33: This update fixes a bug where the history graph tooltips could display the wrong data point and reduces the memory footprint of the structures that store graph history.
Autoruns v9.39: This Autoruns update fixes a couple of minor bugs and adds a new Windows 7 location.

Source: Sysinternals Site Discussion
Process Explorer v11.33
Autoruns v9.39

IE7Pro is a must have add-on for Internet Explorer, which includes a lot of features and tweaks to make your IE friendlier, more useful, secure and customizable. IE7Pro includes Tabbed Browsing Management, Spell Check, Inline Search, Super Drag Drop, Crash Recovery, Proxy Switcher, Mouse Gesture, Tab History Browser, Web Accelerator, User Agent Switcher, Webpage Capturer, AD Blocker, Flash Block, Greasemonkey like User Scripts platform, User Plug-ins, MiniDM, Google sponsored search,IE Faster and many more power packed features. You can customize not just Internet Explorer, but even your favorite website according to your need and taste using IE7Pro.
Changelogs: IE7Pro v2.4.5 (02/04/09):
1. Fixed some bugs.

Download & Info

Mozilla has released version Firefox 3.0.6. It contains security and stability fixes.
Download Firefox 3.0.6.

Whats New:

v2.16.830
– Google Chrome v2.0 compatibility fixes.
– Improved Firefox support when browser is open.
– Improved SeaMonkey support.
– Added Publisher to the uninstall tool.
– Many translation updates.
– Several updates to installer code.
– Cookie options loading now fully threaded.
– Lots of minor interface improvements.
– Minor performance improvements.

Download CCleaner (slim)

This has not been officially released (yet). Major Geeks has it posted so checked the OO mirrors and yep, it’s out.
Download OpenOffice.org For Windows 3.0.1 Final from Major Geeks.
I’ll update this post with the release notes when it is official.

edit – 27JAN2009
OpenOffice.org 3.0.1 is now officially released.
Release Notes

Release History:
MediaMonkey 3.0.7.1191
5209 Update hash calculation for iPhone / iPod Touch sync

Download

MS Sysinternals Tools Updated.

Process Explorer v11.32: This update fixes a bug in the process security page’s name resolution and uses history graph tooltips that track the mouse.
Autoruns v9.38: This fixes a bug that prevented v9.37 from viewing the system account’s profile on 32-bit Windows.

More at the Sysinternals Blog