One Cumulative Update and a 1 or 2 .NET updates depending on which version you’ve installed.
20H2 & 2004: February 9, 2021—KB4601319 (OS Builds 19041.804 and 19042.804)
1909: February 9, 2021—KB4601315 (OS Build 18363.1377)
O&O ShutUp10 Updated
“FIX: Determining registry key permissions has resulted in fewer displayed settings on some NT domain systems.”
If you aren’t on a corporate network (domain) then don’t bother with this update.
Download | Changelog
Google Chrome will no longer support dusty old computers from the mid-2000s
“Though admittedly small, the user base for Chrome users on devices dating back to the early to mid-2000s still exists. A new policy document published by the Chromium development team states that they will be dropping support for processors that lack something called SSE3, or Streaming SIMD Extensions 3, in x86 Chrome builds.”
SSE3 from Wikipedia:
“Intel introduced SSE3 in early 2004 with the Prescott revision of their Pentium 4 CPU. In April 2005, AMD introduced a subset of SSE3 in revision E (Venice and San Diego) of their Athlon 64 CPUs.”
From Intel: Products formerly Prescott